On 17th and 18th April 2021, the Italian stage of the Paralympic swimming World Series will be held in the swimming pool of the Bella Italia village of Lignano Sabbiadoro. The world's strongest athletes will battle it out in a key event ahead of the European Championships and the Tokyo Paralympics.
- 42 participating nations (more numerous teams: Italy 61, Brasil 23, Germany 19, Holland 18, Turkey 17, Great Britain 15, France 14, Kazakhstan 12)
- 261 foreign athletes
- 61 italian athlets
- 322 athletes in total
- 11 world record holders who will swim in the race in which they hold the record (Gabriel dos Santos Araujio (BRA), Reece Dunn (GBR), Alice Tai (GBR), Simone Barlaam (ITA), Carlotta Gilli (ITA), Efrem Morelli (ITA), Federico Morlacchi (ITA), Liesette Bruinsma (NED), Chantalle Zijderveld (NED), Darko Duric (SLO), Julia Gaffney (USA).
- 26 athletes from 11 nations currently in 1st place in the Tokyo 2020 Paralympics ranking (Wendell Belarmino Pereira (BRA), Daniel da Faria Dias (BRA), Maria Carolina Gomes Santiago (BRA), Phelipe Andrews (BRA), Edenia Nogueira Garcia (BRA), Dino Sinovcic (CRO), Reece Dunn (GBR), Louise Fiddes (GBR), Tully Kearney (GBR), Alice Tai (GBR), Dimosthenis Michalentzakis (GRE), Simone Barlaam (ITA), Francesco Bocciardo (ITA), Antonio Fantin (ITA), Carlotta Gilli (ITA), Efrem Morelli (ITA), Federico Morlacchi (ITA), Stefano Raimondi (ITA), Arianna Talamona (ITA), Liesette Bruinsma (NED), Rogier Dorsman (NED), Chantalle Zijderveld (NED), Anna Krivshina (RUS), Sumeyye Boyaci (TUR), Julia Gaffney (USA), Mikaela Jenkins (USA).